publications

Publications in deep learning, drug discovery, NMR spectroscopy, and structural biology

2025

  1. S. Dicks, L. Heumos, S. Jimenez, P. Angerer, I. Gold, I. Virshup, F. Fischer, L. May, C. J. Nolet, M. Gill, M. Boerries, and F. Theis
    Accelerating single-cell analysis with GPU-enabled RAPIDS-singlecell.
    In preparation
  2. E. Sevgen, J. Moller, A. Lange, J. Parker, S. Quigley, J. Mayer, P. Srivastava, S. Gayatri, D. Hosfield, M. Korshunova, M. Livne, M. Gill, R. Ranganathan, A.B. Costa, and A.L. Ferguson
    ProT-VAE: Protein transformer variational autoencoder for functional protein design.
    Proceedings of the National Academy of Sciences 122 (2025)

2024

  1. P. St. John, D. Lin, P. Binder, M. Greaves, V. Shah, J. St. John, A. Lange, P. Hsu, R. Illango, A. Ramanathan, A. Anandkumar, D.H. Brookes, A. Busia, A. Mahajan, S. Malina, N. Prasad, S. Sinai, L. Edwards, T. Gaudelet, C. Regep, M. Steinegger, B. Rost, A. Brace, K. Hippe, L. Naef, K. Kamata, G. Armstrong, K. Boyd, Z. Cao, H.Y. Chou, S. Chu, A. Santos Costa, S. Darabi, E. Dawson, K. Didi, C. Fu, M. Geiger, M. Gill, D.J. Hsu, G. Kaushik, M. Korshunova, S. Kothen-Hill, Y. Lee, M. Liu, M. Livne, Z. McClure, J. Mitchell, A. Moradzadeh, O. Mosafi, Y. Nashed, S. Paliwal, Y. Peng, S. Rabhi, F. Ramezanghorbani, D. Reidenbach, C. Ricketts, B.C. Roland, K. Shah, T. Shimko, H. Sirelkhatim, S. Srinivasan, A.C. Stern, D. Toczydlowska, S.P. Veccham, N.A.E. Venanzi, A. Vorontsov, J. Wilber, I. Wilkinson, W.J. Wong, E. Xue, C. Ye, X. Yu, Y. Zhang, G. Zhou, B. Zandstein, A. Chacon, P. Sohani, M. Stadler, C. Hundt, F. Zhu, C. Dallago, B. Trentini, E. Kucukbenli, T. Rvachov, E. Calleja, J. Israeli, H. Clifford, R. Haukioja, N. Haemel, K. Tretina, N. Tadimeti, and A.B. Costa
    BioNeMo Framework: a modular, high-performance library for AI model development in drug discovery.
    arXiv (2024)
  2. M.T. Strauss, I. Bludau, W.F. Zeng, E. Voytik, C. Ammar, J. Schessner, R. Illango, M.L. Gill, F. Meier, S. Willems, and M. Mann
    AlphaPept, a modern and open framework for MS-based proteomics.
    Nature Communications 15 (2024)

2022

  1. M.L. Gill
    The rise of the machines in chemistry.
    Magnetic Resonance in Chemistry 60, 1044–1051 (2022)
  2. D. Reidenbach, M. Livne, R.K. Illango, M.L. Gill, and J.I. Israeli
    Improving small molecule generation using mutual information machine.
    arXiv (2022)
    Poster presented at ICLR Machine Learning for Drug Discovery Workshop, 2023 Poster Abstract

2019

  1. M.L. Gill, A. Hsu, and A.G. Palmer
    Detection of chemical exchange in methyl groups of macromolecules.
    Journal of Biomolecular NMR 73, 443–450 (2019)
    Poster presented at 57th Experimental Nuclear Magnetic Resonance Conference, Pittsburgh, PA, 2016 Poster

2017

  1. M. Tong, J. Pelton, M.L. Gill, W. Zhang, F. Picart, and M. Seeliger
    Survey of solution dynamics in Src kinase reveals cross talk between the ligand binding and regulatory sites.
    Nature Communications 8, 2160 (2017)

2016

  1. M.L. Gill, R.A. Byrd, and A.G. Palmer
    Dynamics of GCN4 facilitate DNA interaction: a model-free analysis of an intrinsically disordered region.
    Physical Chemistry and Chemical Physics 18, 5839–5849 (2016)
    Poster presented at International Conference on Magnetic Resonance in Biological Systems, Dallas, TX, 2014 Poster
    Poster presented at 57th Experimental Nuclear Magnetic Resonance Conference, Pittsburgh, PA, 2016 Poster

2015

  1. S. Sun, M.L. Gill, Y. Li, M. Huang, and R.A. Byrd
    Efficient and generalized processing of multidimensional NUS NMR data: the NESTA algorithm and comparison of regularization terms.
    Journal of Biomolecular NMR 62, 105–117 (2015)
    Poster presented at 56th Experimental Nuclear Magnetic Resonance Conference, Monterey, CA, 2015 Poster
    Poster presented at 57th Experimental Nuclear Magnetic Resonance Conference, Pittsburgh, PA, 2016 Poster

2014

  1. B. Ergel, M.L. Gill, L. Brown, B. Yu, A.G. Palmer, and J.F. Hunt
    Protein dynamics control the progression and efficiency of the catalytic reaction cycle of AlkB.
    Journal of Biological Chemistry 289, 29584–29601 (2014)
    Poster presented at International Conference on Magnetic Resonance in Biological Systems, Lyon, France, 2012 Poster
  2. M.L. Gill and R.A. Byrd
    Dynamic activation of apoptosis: conformational ensembles of cIAP1 are linked to a spring-loaded mechanism.
    Nature Structural Molecular Biology 21, 1022–1023 (2014)
  3. M.L. Gill and A.G. Palmer
    Local isotropic diffusion approximation for coupled internal and overall molecular motions in NMR spin relaxation.
    Journal of Physical Chemistry B 118, 11120–11128 (2014)

2011

  1. M.L. Gill and A.G. Palmer
    Multiplet-filtered and gradient-selected zero-quantum TROSY experiments for 13C1H3 methyl groups in proteins.
    Journal of Biomolecular NMR 51, 245–251 (2011)
    Poster presented at 52nd Experimental Nuclear Magnetic Resonance Conference, Monterey, CA, 2011 Poster

2009

  1. J.D. Ramsey, M.L. Gill, T.J. Kamerzell, E.S. Price, S.B. Joshi, S.M. Bishop, C.N. Oliver, and C.R. Middaugh
    Using empirical phase diagrams to understand the role of intramolecular dynamics in immunoglobulin G stability.
    Journal of Pharmaceutical Sciences 98, 2432–2447 (2009)

2006

  1. M.L. Gill, S.A. Strobel, and J.P. Loria
    Crystallization and characterization of the thallium form of the Oxytricha nova G-quadruplex.
    Nucleic Acids Research 34, 4506–4514 (2006)

2005

  1. H. Beach, R. Cole, M.L. Gill, and J.P. Loria
    Conservation of µs-ms enzyme motions in the apo- and substrate-mimicked state.
    Journal of the American Chemical Society 127, 9167–9176 (2005)
  2. M.L. Gill, S.A. Strobel, and J.P. Loria
    205Tl NMR methods for the study of monovalent metal binding sites in nucleic acids.
    Journal of the American Chemical Society 127, 16723–16732 (2005)

2004

  1. P.L. Adams, M.R. Stahley, M.L. Gill, A.B. Kosek, J. Wang, and S.A. Strobel
    Crystal structure of a group I intron splicing intermediate.
    RNA 10, 1867–1887 (2004)

2003

  1. C.M. Wiethoff, M.L. Gill, G.S. Koe, J.G. Koe, and C.R. Middaugh
    A fluorescence study of the structure and accessibility of plasmid DNA condensed with cationic gene delivery vehicles.
    Journal of Pharmaceutical Sciences 92, 1272–1285 (2003)

2002

  1. C.M. Wiethoff, M.L. Gill, G.S. Koe, J.G. Koe, and C.R. Middaugh
    The structural organization of cationic lipid-DNA complexes.
    Journal of Biological Chemistry 277, 44980–44987 (2002)

2000

  1. S. Silchenko, M.L. Sippel, O. Kuchment, D.R. Benson, A.G. Mauk, A. Altuve, and M. Rivera
    Hemin is kinetically trapped in cytochrome b5 from rat outer mitochondrial membrane.
    Biochemical and Biophysical Research Communications 273, 467–472 (2000)